Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotoxicity to colorectal cancer cells
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چکیده
منابع مشابه
Oxaliplatin-Induced Neuropathy in Colorectal Cancer
Oxaliplatin use in palliative and adjuvant treatment of colon cancer is frequently limited by cumulative neurotoxicity, leading to reduced quality of life and decreased dose. The mechanism of this neurotoxicity is unclear, but may relate to neuronal voltage-gated sodium channels involving calcium chelation by a metabolite of the drug. Various preventative measures have been tested to reduce the...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2007
ISSN: 0007-0920,1532-1827
DOI: 10.1038/sj.bjc.6603549